Motto, David, M.D./Ph.D.

David Motto
Assistant Professor
Internal Medicine
Office room number: 
3269
Office building: 
CBRB
Office phone: 
319-335-9399
FAX: 
319-353-8383
Lab room number: 
3283
Lab building: 
CBRB
Lab phone: 
319-353-5632
Research

Platelet biology, vascular biology, and diseases of hemostasis and thrombosis (blood clotting).

Our laboratory is interested in the biochemistry, physiology, and genetics of blood clotting diseases. A strong current focus is on the thrombotic microangiopathies (TMAs), which are characterized clinically by small blood vessel thrombosis of various organs, coupled with thrombocytopenia (low blood platelets) and the physical destruction of red blood cells. The two most common TMAs are thrombotic thrombocytopenic purpura (TTP) and the closely-related hemolytic-uremic syndrome (HUS). Recently we have developed a mouse model of TTP which has provided significant insight into this disease. We are using this model to study TTP pathophysiology, and to identify environmental triggers and genetic modifying factors for TTP and other TMA disorders.

Selected publications: 

Trionfini, P., Tomasoni, S., Galbusera, M., Motto, D., Longaretti, L., Corna, D., Remuzzi, G., and Benigni, A. Adenoviral-mediated gene transfer restores plasma ADAMTS13 antigen and activity in ADAMTS13 knockout mice. Gene Ther. 2009 Aug 13. [Epub ahead of
print]

Lerolle, N., Dunois-Lard, C., Badirou, I., Motto, D.G., Hill, G., Bruneval, P., Diehl, J.L., Denis, C.V., and Baruch, D. von Willebrand factor is a major determinant of ADAMTS-13 decrease during mouse sepsis induced by cecum ligation and puncture. J Thromb Haemost. 7(5):843-50, 2009.

Niiya, M., Endo, M., Shang, D., Zoltick, P.W., Muvarak, N.E., Cao, W., Jin, S.Y., Skipwith, C.G., Motto, D.G., Flake, A.W., and Zheng, X.L. Correction of ADAMTS13 deficiency by in utero gene transfer of lentiviral vector encoding ADAMTS13 genes. Mol Ther. 17(1):34-41, 2009.

Chauhan, A.K., Walsh, M.T., Zhu, G., Ginsburg, D., Wagner, D.D., and Motto, D.G. The combined roles of ADAMTS13 and VWF in murine models of TTP, endotoxemia, and thrombosis. Blood 111(7):3452-7, 2008.

Motto, D., Roltsch, M., and Poncz, M. Mechanisms for mentored career development: the NIH research career awards and other national awards. Hematology Am Soc Hematol Educ Program. 504-8, 2007.

Department/Program affiliations: 
Pediatrics