Zabner, Joseph, M.D.

Joseph Zabner
Professor
Internal Medicine
Office room number: 
C33-G
Office building: 
GH
Office phone: 
319-384-5401
Lab room number: 
440
Lab building: 
EMRB
Lab phone: 
319-335-7608
Lab website: 
http://genetherapy.genetics.uiowa.edu/
Research

Gene transfer to human airway epithelia

Dr. Zabner's research interests are in gene transfer to human airway epithelia in particular to develop gene therapy for cystic fibrosis. Dr. Zabner also has an interest in the fluid composition of the airway surface liquid, and how it affects innate immunity. His clinical interests are in cystic fibrosis and non-cystic fibrosis bronchiectasis.

Selected publications: 

Vermeer, P.D., Denker, J., Estin, M., Moninger, T.O., Keshavjee, S., Karp, P., Kline, J.N., and Zabner, J.. MMP9 Modulates Tight Junction Integrity and Cell Viability in Human Airway Epithelia. Am J Physiol Lung Cell Mol Physiol, in press 2009.

Excoffon, K.J., Koerber, J.T., Dickey, D.D., Murtha, M., Keshavjee, S., Kaspar, B.K., Zabner, J., and Schaffer, D.V. Directed Evolution of Adeno-Associated Virus to an Infectious Respiratory Virus. Proc. Natl. Acad. Sci. USA., 106(10): 3865-3870; 2009.

Stoltz, D.A., Ozer, E.A., Taft, P.J., Barry, M., Liu, L., Kiss, P.J., Moninger, T.O., Parsek, M.R., and Zabner, J.. Drosophila are Protected from Pseudomonas Aeruginosa Lethality by Transgenic Expression of Paraoxonase-1. J. Clin. Invest., 118(9): 3123-3131; 2008.

Excoffon, K.J., Guglielmi, K.M., Wetzel, J.D., Gansemer, N.D., Campbell, J.A., Dermody, T.S., and Zabner, J.. Reovirus Preferentiality Infects the Basolateral Surface and is Released from the Apical Surface of Polarized Human Respiratory Epithelial Cells. J. Infect. Dis., 197(8): 1189-1197; 2008.

Department/Program affiliations: 
Biosciences
Molecular and Cellular Biology
MSTP